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Synaptic Adaptation Arc Therapy – spontaneous activity of synapses

Tinnitus causes and plasticity type: spontaneous activity of synapses


At the beginning, every patient with tinnitus experiences spontaneous activity of synapses. Since the emergence of sudden hearing loss and activity decline of the auditory synaptic nerve, upper neurons of the auditory pathway increase their natural activity due to stimulation decrease. In neurobiology, it’s a natural process called synaptic scaling. Greater and more sensitive activity of synapses appears as shriek or hearing tinnitus. It’s the first stage of tinnitus which lasts from 2 to 3 years starting from sudden hearing loss and hiss emergence. Despite the first years of life, the nervous system is connected with auditory cells by a proper amount of fibers, therefore, acoustic stimulation of the environment hushes down synaptic hiss. However, a cell stimulation decrease is noticeable and the hiss becomes hearable again. If tinnitus is reduced at this stage, the nervous system won’t take another step forward in terms of plasticity, name enhanced synchronization.


We might say that each patient goes throught the same path. At first, tinnitus appears as spontaneous activity of synapses as a result of sudden decline of stimulation in the inner ear, caused by sudden hearing loss; it lasts approximately 2-3 years. Then, the nervous system acknowledges despite sensitivity and increased activity is unable to get an effective stimulation for neurons. Then, the nervous system decides to disclaim synapses and connections with cells burden with sudden hearing loss. As a result, it activates the process of fibers migration from unstimulated neurons to fibers and synapses with natural access to dynamics of hearing in ranges free of hearing loss. After 2-3 years, a spontaneous activity model transforms into a model of enhanced synchronization.


Typical symptoms: tinnitus disappears with the presence of auditory threshold

Type of tinnitus: Tinnitus of spontaneous activity changes its own character after two or three years due to changes that occurred in the nervous system. It takes over the enhanced synchronization model.

The cost of therapy : 2500 Euro 

Reduction technology

  • 80%

    Tinnitus reduction equal with 80 to 100 %

  • 20%

    Tinnitus reduction below 80 %

Effectivness of tinnitus reduction in spontaneous activity model  with diet and  physical activity in clinical research :


Tinnitus spontaneous activity model can by reduced by adaptation auditory nervous system after sudden hearing loss. Effectivness of new tinnitus treatment Synaptic

adaptation Arc therapy - Adam Pabiś , Joanna Białczak , J.K Skrzypicka , Stanisław Sławicki(Pub Connection Journal of Neuroscience 2014 )

How does the process of adjusting settings of my device to my tinnitus look like?

After online testing or having been tested in our clinic, specialists will set the processors for you. The program and stimulation are adjusted automatically. A device’s protocols are programmed by a technician and they will be remotely changed every day, so a patient doesn’t have to change a anything. In this respect, a patient can visit us only once and never show up again, yet the therapy and its course will remain adjusted. This innovative approach makes it easier for patients to focus exclusively on keeping healthy diet and physical activity. Stimulation matches patient’s hearing threshold in the range of sudden hearing loss and is created in three-dimensional technology (3D). Within time, stimulation changes into frequency and intensity; thus, every cell and its synapse receive an accurate adaptation level without intensity structure omission. How is the device constructed? Is it easy to use? We provide two models of stimulation devices: Modulator ARC-3 and Modulator ARC-3.1. Both of them are small and easy to use, but the difference lies in the number of protocols to be operated by each of two devices. Modulator ARC-3 is a basic device with a stimulation program, on/off button, sound control of right and left channels, USB port for charging and using CIC earphones. Modulator ARC-3.1 device is of similar size but it can operate a greater number of stimulation protocols. It also has a sound control of both channels, similar power supply and remote control of settings. After your online consultation or an appointment in our clinic, you will receive a device with a user manual and all necessary information.

Can it take less than 6 months to have any effects?

Our therapy is very similar to physical exercises: the most effective ones are the ones we perform last. In order for them to be effective, you need to do the first ones. A therapy we provide works in the same way. If the signal is weak and occurs rarely, it’s quite obvious that activity of synapses during therapy will be lower than at the beginning when the stimulation is strong and more frequent. Some patients notice gradual reduction, some – sudden, while others experience dulling of the hiss, which is silent and hushed down in certain situations. However, we consider final results of a therapy more important than partial results.

For how long do I have to wear the stimulation device?

It’s an individual aspect of how long we are physically able to wear a device; an average time is 9 hours a day, not necessarily in a row. Actually, it’s recommended to take breaks because the longer you wear it, the lower the amount of synaptic vesicles is because they need time to rebuild themselves. Some patients can wear a device the whole day, but others only after work. Everything depends on how your day is organized. Some consider it as inconvenient, especially during professional meetings, while others don’t mind it at all. When it comes to its functioning, the device measures stimulation time, therefore, we remain up-to-date with whether or not a patient wears a device long enough.

What if a therapy won’t reduce my tinnitus?

It’s impossible, unless we have an additional region in our brain which modulates activity of the auditory cortex. Then it’s required to take MRI test in order to indicate which brain region interacts with hyperactivity. Another step would be lessening its activity with rTMS. In some cases, activity of regions and another path between regions becomes plasticized. However, if we’ve suffered from tinnitus for 2-3 years such situations is unlikely to arise. It often occurs to patients with 10 or 20-years tinnitus experience.

I have been running for quiet a time, can I begin my therapy right away?

Being physically active makes it easier and helps in a therapy process, unfortunately, not always. It’s not the case if, but what kind of sport we’ve been practicing. Production of neurotrophic proteins BDNF always takes place after physical activity was performed. A type of activity determines for how long the highest concentration of this proteins will sustain. We can run, swim or ride a bike and it’s perfectly fine from neuropharmalogical perspective. After such activities, the proteins level will increase within an hour, but our goal is to have it for 24h. There is a few training programs and correlations with diet that make it possible.

If I’m diagnosed with spontaneous activity tinnitus model, can I use rTMS?

Of course, you can but it won’t be effective. If you’re willing to waste money and blindly follow something what’s been known and ineffective for some time now, we can’t stop you. If, on the other hand, your goal is a visible effect, we recommend therapy in accordance with diagnostics and test results. A broken leg shouldn’t be treated with oncology drugs and the other way around. Neurobiology is no different: We reduce tinnitus in regard to what has changed. For instance, if the hiss has been present for months, our problem doesn’t lie in enhanced synchronization which hasn’t yet emerged. Therefore, transcranial stimulation won’t appear helpful, because we would be facing spontaneous activity. We shouldn’t expect any results until the problem connected with this model is solved. This information gives out an answer to a question of why an effective tinnitus treatment hasn’t been invented. As you have probably noticed, we don’t use a word effective at our subpages. Effectiveness is connected with something not necessarily matched, and we’re not necessarily certain would help. Once you know that black is black and white – white, it’s harder to make a mistake. We observe the same situation with effectiveness which is determined by a suitable technology match to a particular model, not by technology in itself. As I have already clarified, it’s impossible to be successful when using the same treatment method for a patient who’s had tinnitus for 2 years and another one who’s suffered from this for 6 years.

Reduction technology of spontaneous activity with Synaptic Adaptation Arc Therapy

Due to the sustained structure auditory cell-neuron, we use acoustic stimulation beacuse we are able to perform effective move stimulation and influence activity of synapses and neurons of the auditory pathway. Spontaneous activity model is a symptom of the nervous system’s lack of accurate adaptation, not lessening the number of neurons and fibers in relation to lessened stimulation. For this particular model, our selection is Synaptic Adaptation Arc Therapy, which goal is to adapt the nervous system to a lessen stimulation. A patient with increasing hearing loss lacks tinnitus. It’s connected with a fact that the amount of the stimulation received by the inner ear and the nervous system evenly lessens. The nervous system has time to implement changes. The number of neurons decreases, the connections weaken, the nervous system’s size and activity is adjusted adequately to a lower level of stimulation. During this process, a special kind of cytoskeletal proteins called Arc/Arg 3.1 is released. Proteins are produced when the nervous system is in the process of learning or deriving. As research shows, production of proteins is disturbed because of the sudden hearing loss. During sudden hearing loss, cells die so fast that the nervous system doesn’t have time to adjust its size and weight to the activity decline which emerged. In such case, a symptom of sudden hearing loss is inadequate development of the nervous system in relation to activity of damaged cells. During silence, our nervous system increases its activity, and the above mentioned situation is no different. Due to sudden loss stimulation from cells, synapses increase their activity. The only effective way to reduce tinnitus is adapting the nervous system to worse hearing and our Synaptic Adaptation Arc Therapy provides that. It activates a range of auditory cells in the area of other damaged cells which stimulation lowers within time. Day by day, a patient perceives that lowering stimulation. Because of this process, less and less neurotransmitters are released from cells to synapses. As a result, proteins Arc/Arg 3.1 are produced. We move the nervous system into adaptation stage, which was created superficially by our technology. After a longer period of time, synapses’ activity and weight is decreased. As (…) presents in his (ALBO HER, nie wiem kim jest autor) research study, spontaneous activity from synapses is released more rarely because the nervous system analyzes and adjusts activity of synapses to signal frequency. Thus, if we the nervous system is  with lower stimulation it starts adapting to a situation in which less stimulation should be analyzed.


An average time of therapy in sessions: a patient receives a portable device to take home  

Duration of therapy: 6-12 months

Cost of complete therapy: from 2500  to 3500 Euro (depending on the amount of synapses to be adapted)

Required medical tests: tinnitus characteristics up to 20 kHz, horizontal fibers of the auditory cortex, activity of the corpus callosum fibers