Synaptic Adaptation Arc Therapy – spontaneous activity of synapses
Tinnitus causes and plasticity type: spontaneous activity of synapses
At the beginning, every patient with tinnitus experiences spontaneous activity of synapses. Since the emergence of sudden hearing loss and activity decline of the auditory synaptic nerve, upper neurons of the auditory pathway increase their natural activity due to stimulation decrease. In neurobiology, it’s a natural process called synaptic scaling. Greater and more sensitive activity of synapses appears as shriek or hearing tinnitus. It’s the first stage of tinnitus which lasts from 2 to 3 years starting from sudden hearing loss and hiss emergence. Despite the first years of life, the nervous system is connected with auditory cells by a proper amount of fibers, therefore, acoustic stimulation of the environment hushes down synaptic hiss. However, a cell stimulation decrease is noticeable and the hiss becomes hearable again. If tinnitus is reduced at this stage, the nervous system won’t take another step forward in terms of plasticity, name enhanced synchronization.
We might say that each patient goes throught the same path. At first, tinnitus appears as spontaneous activity of synapses as a result of sudden decline of stimulation in the inner ear, caused by sudden hearing loss; it lasts approximately 2-3 years. Then, the nervous system acknowledges despite sensitivity and increased activity is unable to get an effective stimulation for neurons. Then, the nervous system decides to disclaim synapses and connections with cells burden with sudden hearing loss. As a result, it activates the process of fibers migration from unstimulated neurons to fibers and synapses with natural access to dynamics of hearing in ranges free of hearing loss. After 2-3 years, a spontaneous activity model transforms into a model of enhanced synchronization.
Typical symptoms: tinnitus disappears with the presence of auditory threshold
Type of tinnitus: Tinnitus of spontaneous activity changes its own character after two or three years due to changes that occurred in the nervous system. It takes over the enhanced synchronization model.
The cost of therapy : 2500 Euro
Reduction technology
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80%
Tinnitus reduction equal with 80 to 100 %
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20%
Tinnitus reduction below 80 %
Effectivness of tinnitus reduction in spontaneous activity model with diet and physical activity in clinical research :
Tinnitus spontaneous activity model can by reduced by adaptation auditory nervous system after sudden hearing loss. Effectivness of new tinnitus treatment Synaptic
adaptation Arc therapy - Adam Pabiś , Joanna Białczak , J.K Skrzypicka , Stanisław Sławicki(Pub Connection Journal of Neuroscience 2014 )
Reduction technology of spontaneous activity with Synaptic Adaptation Arc Therapy
Due to the sustained structure auditory cell-neuron, we use acoustic stimulation beacuse we are able to perform effective move stimulation and influence activity of synapses and neurons of the auditory pathway. Spontaneous activity model is a symptom of the nervous system’s lack of accurate adaptation, not lessening the number of neurons and fibers in relation to lessened stimulation. For this particular model, our selection is Synaptic Adaptation Arc Therapy, which goal is to adapt the nervous system to a lessen stimulation. A patient with increasing hearing loss lacks tinnitus. It’s connected with a fact that the amount of the stimulation received by the inner ear and the nervous system evenly lessens. The nervous system has time to implement changes. The number of neurons decreases, the connections weaken, the nervous system’s size and activity is adjusted adequately to a lower level of stimulation. During this process, a special kind of cytoskeletal proteins called Arc/Arg 3.1 is released. Proteins are produced when the nervous system is in the process of learning or deriving. As research shows, production of proteins is disturbed because of the sudden hearing loss. During sudden hearing loss, cells die so fast that the nervous system doesn’t have time to adjust its size and weight to the activity decline which emerged. In such case, a symptom of sudden hearing loss is inadequate development of the nervous system in relation to activity of damaged cells. During silence, our nervous system increases its activity, and the above mentioned situation is no different. Due to sudden loss stimulation from cells, synapses increase their activity. The only effective way to reduce tinnitus is adapting the nervous system to worse hearing and our Synaptic Adaptation Arc Therapy provides that. It activates a range of auditory cells in the area of other damaged cells which stimulation lowers within time. Day by day, a patient perceives that lowering stimulation. Because of this process, less and less neurotransmitters are released from cells to synapses. As a result, proteins Arc/Arg 3.1 are produced. We move the nervous system into adaptation stage, which was created superficially by our technology. After a longer period of time, synapses’ activity and weight is decreased. As (…) presents in his (ALBO HER, nie wiem kim jest autor) research study, spontaneous activity from synapses is released more rarely because the nervous system analyzes and adjusts activity of synapses to signal frequency. Thus, if we the nervous system is with lower stimulation it starts adapting to a situation in which less stimulation should be analyzed.
An average time of therapy in sessions: a patient receives a portable device to take home
Duration of therapy: 6-12 months
Cost of complete therapy: from 2500 to 3500 Euro (depending on the amount of synapses to be adapted)
Required medical tests: tinnitus characteristics up to 20 kHz, horizontal fibers of the auditory cortex, activity of the corpus callosum fibers