Reduction of tinnitus caused by hyperactivity of the corpus callosum fibers
Treatment methods: Memantine or musical training
During acoustic trauma, it’s likely to observe damage of the outer auditory cells as well as damage of the neurons in the auditory cortex. In such situation, a patient usually perceives tinnitus in both ears, but the diagnostics shows unilateral acoustic trauma. If we perform a test to measure activity of the corpus callosum fibers it will show a typical damage of neurons in one of two auditory cortexes. Sudden burn-out of the neurons means a loss of stimulation of a synapse which was connected with a corpus callosum fiber. Exactly the same process emerged with sudden death of the auditory cells in outlying part of neurons of the auditory pathway but on the level of cortical connections. With sudden activity decline caused by death of neurons, a synapse of the corpus callosum fiber increases its activity. Spontaneous activity leads through the whole length of the fiber to the neuron of the auditory cortex in the opposite cerebral hemisphere. It emerges as bilateral tinnitus. Hushing down tinnitus on both sides, with stimulating one side where neurons of the auditory cortex aren’t damaged, is typical for an examination process of a corpus callosum fiber. If a patient visits us within 4 days from acoustic trauma occurrence, we will use a medication called memantine. It’s an antagonist of NMDA receptor and is used in treating disorders of cognitive processes. After 4 days, the medication loses its ability to reduce an excessive activity of synapses in cochlear nuclear.
Technology of reduction
Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy (Christoph M. Krick, Miriam Grapp, Jonas Daneshvar-Talebi, Wolfgang Reith, Peter K. Plinkert and Hans Volker Bolay)
Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy
Enhancing Inhibition-Induced Plasticity in Tinnitus – Spectral Energy Contrasts in Tailor- Made Music Matter Training
Customized music training reduces tinnitus loudness
Reduced volume of Heschl's gyrus in tinnitus patients after sudden hearing loss
Cortical inhibition effect in musicians and non-musicians using P300 with and without contralateral stimulation
Technology of tinnitus reduction caused by hyperactive corpus callosum fibers and generated by acoustic trauma: Musical training therapy or treatment with memantine up to four days since the occurrence of acoustic trauma
When neurons of the auditory cortex are damaged, we observe hyperactivity of the corpus callosum synapses. In order to reduce tinnitus caused by death of neurons from the auditory cortex, we have to use a program of regenerating and reconstructing neurons. Due to this process, corpus callosum synapse is reconnected with a reconstructed neuron of the auditory cortex; hyperactivity and tinnitus disappear. It can be done with help of a short-term musical training which can last up to 6 months. When playing an instrument, an alternating stimulation of neurons from the auditory cortex is performed with sound and somatosensory stimulation. It’s been known for some time now that neurons of the auditory cortex analyze not only audible information but also motional information (proproception). This can be used to fasten the process of neurons reconstruction. In addition, numerous research studies show that during even a short-term musical training, the process of generating new populations of hampering neurons occurs. It also regulates balance of neurotransmition of the auditory cortex after acoustic trauma where neuro-shifting occurred.
Musical training is conducted in our clinics. Each patient can take an attempt to practice on his/her own, and we are willing to help in showing what to do to make neurons reconstruct faster.
If a patient shows up in our clinic, he/she will be treated with memantine up to 4 days. This medication lessens and regulates activity of the tinnitus. Conducted research studies available on our website support its effectiveness.